Research Journal of Pharmacy and Technology

Dolih Gozali ¹, Resmi Mustarichie ²

Affiliations
1 Pharmaceutical Department, Faculty of Pharmacy, Universitas Padjadjaran, ID
2 Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjadjaran, ID

Abstract

Synthetic cosmetic products have been used to unravel the problem of alopecia, yet synthetics are potential to give side effects such as local irritation), whilst herbal products are generally safer. Our previous research showed that water fraction of Angiopteris evecta extract had been proved as had growth hair characteristic. The aim of this study was to formulate hair tonic from water fraction of A.evecta extract which was stable, effective towards hair growth, and safe. The water fraction was into varied of 7.5%, 10.0, and 12.5%. Physical stability test performed was cycling test, storage in high temperature (40°C ± 2°C), room temperature (25°C ± 2°C), and low temperature (4°C ± 2°C). The activity of hair growth test was conducted by hair length measurements using rabbit based on Tanaka method on day 3, 6, 9, 12, 15 and 18 days. Results showed the hair tonic was stable in storage. In addition to giving hair growth activity, the formula had greater activity equal and higher activity compared to controlled minoxidil synthetic drug. The hair tonics were safe and did not irritate skin. The best formulation was formula F3 with a water fraction of 10.0%. It is suggested to carry our hair growth test to bald volunteers in order to verify the effectiveness of this formula before it could be marketed.

Keywords

Angiopteris evecta, Hair Tonic, Formulation, Anti-Alopecia, Hair Growth, Minoxidil.

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Silviana Hasanuddin ¹, Dolih Gozali ², Muhammad Arba ³, Dwi Syah Fitra Ramadhan ⁴, Resmi Mustarichie ¹

Affiliations
1 Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang,, ID
2 Pharmaceutical Department, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang,, ID
3 Faculty of Pharmacy, Universitas Halu Oleo, Kendari,, ID
4 Department of Pharmacy, Universitas Mandala Waluya, Kendari,, ID

Abstract

Introduction: Alopecia is a hair loss that occur continuously and may occur in men, women and children. The causes of alopecia, including the use of cosmetics, medication, stress, postpartum period, hormonal disorders, and scalp infection. The purpose of this research is to determine the compounds contained in Petroselinum crispum that have the potential as antialopecia agents by predicting ligand-receptor binding and binding modes, predicting ADME by using Lipinski's rule, and also comparing the effectiveness with native ligand and minoxidil. Methodology: The process starts with protein and ligand structure preparation, then docking using Autodock Vina. Afterward, analyzed and visualized of the ligands docking, and predicted the ADME according to lipinski's rules using SwissADME and toxicity using PASS predistion. Result: There were 24 compounds found in Petroselinum crispum. Molecular docking simulation showed that six compounds had better binding affinities than minoxidil. Based on the results of prediction of ADMET values using the Lipinski rule and PASS Prediction, compound that are thought to have good activity is (+)–Marmesin compared to minoxidil. Conclusion: (+)–Marmesin to have better interactions with the androgen receptor, but not better than native ligands. thus, (+)–Marmesin can be used as antialopecia agents alternative terapy.

Keywords

Alopecia, Androgen receptor, In silico, Petrocelinum crispum.

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